Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 11/20 | 0.51 |
| ▸ | EDNRB | P24530 | 7/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338516 | 0.85 | EDNRA (0.53) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL7332942 | 0.84 | EDNRA (0.52) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL7339477 | 0.84 | EDNRA (0.59) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL7330171 | 0.82 | EDNRA (0.77) | EDNRAEDNRBAGTR1 | |
| SCHEMBL7332725 | 0.82 | EDNRA (0.58) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL7338422 | 0.81 | EDNRA (0.60) | EDNRAEDNRBAGTR1USP2MAPT | |
| SCHEMBL7329622 | 0.79 | EDNRA (0.57) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL7331707 | 0.78 | EDNRA (0.48) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL8903655 | 0.78 | EDNRA (0.61) | EDNRAEDNRBAGTR1USP2MAPT | |
| SCHEMBL7339641 | 0.77 | EDNRA (0.55) | EDNRAEDNRBAGTR1USP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0774965-A4 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO INC (US) | 1997-10-29 | — | — | EP | disclosed |
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0774965-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO. INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |