Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.59 |
| ▸ | EDNRB | P24530 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338441 | 0.90 | EDNRA (0.60) | EDNRAEDNRBMAPTALDH1A1TSHR | |
| SCHEMBL7332942 | 0.88 | EDNRA (0.52) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL7338516 | 0.87 | EDNRA (0.53) | EDNRAEDNRBTAS1R3TAS1R1AGTR1 | |
| SCHEMBL7329622 | 0.86 | EDNRA (0.57) | EDNRAEDNRBMAPTALDH1A1TSHR | |
| SCHEMBL7333299 | 0.84 | EDNRA (0.51) | EDNRAEDNRBMAPTTAS1R3TAS1R1 | |
| SCHEMBL7339368 | 0.84 | EDNRA (0.61) | EDNRAEDNRBMAPTALDH1A1TSHR | |
| SCHEMBL7332725 | 0.83 | EDNRA (0.58) | EDNRAEDNRBALDH1A1TSHRTAS1R3 | |
| SCHEMBL8903642 | 0.83 | EDNRA (0.60) | EDNRAEDNRBMAPTALDH1A1TSHR | |
| SCHEMBL8789773 | 0.83 | EDNRA (0.58) | EDNRAEDNRBMAPTALDH1A1TSHR | |
| SCHEMBL8903647 | 0.83 | EDNRA (0.60) | EDNRAEDNRBMAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767310-A | Phenoxyphenylacetic acid derivatives | MERCK & CO., INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0774965-A4 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO INC (US) | 1997-10-29 | — | — | EP | disclosed |
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0774965-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO. INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |
| EP-0617001-A1 | Phenoxyphenylacetic acid derivatives | MERCK & CO. INC. (US) | 1994-09-28 | — | — | EP | disclosed |