Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | MAT2A | P31153 | 9/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339577 | 0.86 | PDE5A (0.51) | PDE5APDE4BPDE4DATM | |
| SCHEMBL7334800 | 0.86 | PDE5A (0.55) | PDE5AMAT2APDE4BPDE4DATM | |
| SCHEMBL7331984 | 0.84 | PDE5A (0.49) | PDE5AMAT2APDE4BNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7332007 | 0.83 | PDE5A (0.49) | PDE5AMAT2APDE4BNPC1RAB9A | |
| SCHEMBL7338367 | 0.83 | PDE5A (0.54) | PDE5APDE4BPDE4DAPP | |
| SCHEMBL8388253 | 0.82 | PDE5A (0.52) | PDE5AMAT2APDE4BSMN1; SMN2PDE4D | |
| SCHEMBL7337999 | 0.81 | PDE5A (0.47) | PDE5APDE4BPDE4D | |
| SCHEMBL7332872 | 0.81 | PDE5A (0.52) | PDE5AMAT2APDE4BPDE4DBCHE | |
| SCHEMBL7330127 | 0.81 | PDE5A (0.50) | PDE5APDE4BPDE4DACHE | |
| SCHEMBL7331523 | 0.80 | PDE5A (0.50) | PDE5APDE4BPDE4DAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942520-A | Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines | CELL PATHWAYS, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |