Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.71 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328222 | 0.86 | REN (0.66) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7336163 | 0.83 | REN (0.89) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7327232 | 0.83 | REN (1.00) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7386223 | 0.80 | REN (1.00) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7330067 | 0.80 | REN (1.00) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7335387 | 0.78 | REN (1.00) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7331414 | 0.77 | REN (1.00) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7329655 | 0.77 | REN (0.67) | REN | |
| SCHEMBL7328493 | 0.76 | REN (0.62) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7325745 | 0.74 | REN (0.73) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5095119-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-10 | — | — | US | disclosed |
| US-5075451-A | Pyrrolimidazolones useful as renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-5064965-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-12 | — | — | US | disclosed |
| US-5023338-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |