Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.47 |
| ▸ | PDE4A | P27815 | 11/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333351 | 1.00 | PDE4B (0.47) | PDE4BPDE4ARECQLPDE4DPDE4C | |
| SCHEMBL7381353 | 0.85 | PDE4B (0.59) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7381354 | 0.85 | PDE4B (0.59) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7340266 | 0.82 | PDE4B (0.53) | PDE4BPDE4ARECQLPDE4DPDE4C | |
| SCHEMBL7331685 | 0.81 | PDE4A (0.49) | PDE4BPDE4ARECQLPDE4DPDE4C | |
| SCHEMBL7331695 | 0.81 | PDE4A (0.49) | PDE4BPDE4ARECQLPDE4DPDE4C | |
| SCHEMBL7332185 | 0.80 | PDE4A (0.55) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7332199 | 0.80 | PDE4A (0.55) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL2371289 | 0.78 | PDE4B (0.60) | PDE4BPDE4ARECQLPDE4DPDE4C | |
| SCHEMBL2958828 | 0.77 | RECQL (0.60) | PDE4BPDE4ARECQLPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470805-B1 | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents | AMERICAN HOME PROD (US) | 1994-09-07 | — | — | EP | disclosed |
| US-5124455-A | Enzyme inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0470805-A1 | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-02-12 | — | — | EP | disclosed |