Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | DRD1 | P21728 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335055 | 0.94 | GRIN2B (0.48) | CHRNA7KDM4EALDH1A1DRD2DRD1 | |
| SCHEMBL7329980 | 0.93 | GRIN2B (0.49) | CHRNA7KDM4EALDH1A1DRD2DRD3 | |
| SCHEMBL7327286 | 0.92 | GRIN2B (0.48) | KDM4EALDH1A1DRD2DRD3GRIN2B | |
| SCHEMBL7324986 | 0.89 | KDM4E (0.55) | KDM4EALDH1A1DRD2DRD1DRD4 | |
| SCHEMBL7333718 | 0.88 | DRD2 (0.46) | DRD2DRD1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7328480 | 0.87 | DRD2 (0.49) | DRD2DRD1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7325610 | 0.86 | DRD2 (0.54) | DRD2DRD1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7331002 | 0.83 | DRD2 (0.44) | DRD2DRD1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7325082 | 0.83 | DRD2 (0.46) | DRD2DRD1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7327483 | 0.82 | DRD2 (0.48) | DRD2DRD1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |