Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | WNT3A | P56704 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791812 | 0.88 | EDNRA (0.55) | KMT2ANPC1RAB9AEDNRAALDH1A1 | |
| SCHEMBL2346146 | 0.81 | KMT2A (0.56) | KMT2AEDNRAMEN1ALDH1A1HPGD | |
| SCHEMBL11402001 | 0.78 | MEN1 (0.59) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL4824905 | 0.78 | KMT2A (0.52) | KMT2ANPC1RAB9ACTNNB1WNT3A | |
| SCHEMBL6314113 | 0.75 | KMT2A (0.45) | KMT2AEDNRAMEN1ALDH1A1MAPT | |
| SCHEMBL7329159 | 0.74 | EDNRA (0.53) | KMT2ANPC1RAB9AEDNRAALDH1A1 | |
| SCHEMBL27952103 | 0.73 | KMT2A (0.71) | KMT2AMEN1 | |
| SCHEMBL7331355 | 0.73 | EDNRA (0.51) | KMT2ACTNNB1WNT3AEDNRAMEN1 | |
| SCHEMBL27842527 | 0.73 | KMT2A (0.54) | KMT2ANPC1RAB9ACTNNB1WNT3A | |
| SCHEMBL1580245 | 0.73 | PTGS1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | claimed |
| US-5767310-A | Phenoxyphenylacetic acid derivatives | MERCK & CO., INC. (US) | 1998-06-16 | — | — | US | disclosed |
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |
| WO-1994021590-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1994-09-29 | — | — | WO | disclosed |
| EP-0617001-A1 | Phenoxyphenylacetic acid derivatives | MERCK & CO. INC. (US) | 1994-09-28 | — | — | EP | disclosed |