Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.66 |
| ▸ | C1R | P00736 | 11/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332215 | 0.87 | MAPT (0.58) | ELANEC1RPRSS1 | |
| SCHEMBL7331779 | 0.87 | C1R (0.55) | ELANEC1RPRSS1 | |
| SCHEMBL7333524 | 0.86 | C1R (0.54) | ELANEC1RPRSS1 | |
| SCHEMBL7332663 | 0.86 | C1R (0.51) | ELANEC1RPRSS1 | |
| SCHEMBL8896024 | 0.86 | ELANE (0.67) | ELANEC1RPRSS1 | |
| SCHEMBL7364114 | 0.86 | ELANE (0.67) | ELANEC1RPRSS1 | |
| SCHEMBL7366730 | 0.85 | ELANE (0.66) | ELANEC1RPRSS1 | |
| SCHEMBL7364205 | 0.85 | ELANE (0.66) | ELANEC1RPRSS1 | |
| SCHEMBL7369323 | 0.85 | ELANE (0.66) | ELANEC1RPRSS1 | |
| SCHEMBL7332212 | 0.85 | C1R (0.53) | ELANEC1RPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |