Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.66 |
| ▸ | C1R | P00736 | 10/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364114 | 0.86 | ELANE (0.67) | ELANEC1RPRSS1 | |
| SCHEMBL8896024 | 0.86 | ELANE (0.67) | ELANEC1RPRSS1 | |
| SCHEMBL7369323 | 0.85 | ELANE (0.66) | ELANEC1RPRSS1 | |
| SCHEMBL7333602 | 0.85 | ELANE (0.66) | ELANEC1RPRSS1 | |
| SCHEMBL7366730 | 0.85 | ELANE (0.66) | ELANEC1RPRSS1 | |
| SCHEMBL7337724 | 0.84 | ELANE (0.62) | ELANEC1RPRSS1 | |
| SCHEMBL7332639 | 0.83 | ELANE (0.63) | ELANEC1RPRSS1NPC1ALDH1A1 | |
| SCHEMBL7332148 | 0.83 | ELANE (0.63) | ELANEC1RPRSS1RAB9A | |
| SCHEMBL7333539 | 0.83 | ELANE (0.74) | ELANEC1RPRSS1NPC1RAB9A | |
| SCHEMBL7332303 | 0.80 | ELANE (1.00) | ELANEC1RPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |