Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 8/20 | 0.63 |
| ▸ | F2 | P00734 | 3/20 | 0.63 |
| ▸ | PLG | P00747 | 3/20 | 0.63 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.63 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22695574 | 0.87 | POLB (0.75) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL7335211 | 0.86 | PLAU (0.74) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL7334216 | 0.85 | PLAU (0.70) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL20379456 | 0.85 | MEN1 (0.73) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL28013893 | 0.81 | PLAU (0.74) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL679200 | 0.81 | DEGS1 (0.74) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL7335241 | 0.77 | PLAU (0.62) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL28013896 | 0.77 | PLAU (0.68) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL5561129 | 0.77 | PLAU (1.00) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL9337665 | 0.77 | MLYCD (0.76) | PLAUF2PLGKLKB1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |
| US-6258822-B1 | ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-07-10 | — | — | US | disclosed |