Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 13/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9075667 | 0.95 | F2 (0.50) | F2PRSS1PRSS2PRSS3CMA1 | |
| SCHEMBL9076059 | 0.93 | CMA1 (0.48) | F2PRSS1PRSS2PRSS3CMA1 | |
| SCHEMBL9073832 | 0.91 | F2 (0.54) | F2PRSS1PRSS2PRSS3CMA1 | |
| SCHEMBL7346760 | 0.91 | F2 (0.54) | F2PRSS1PRSS2PRSS3CMA1 | |
| SCHEMBL9073529 | 0.91 | F2 (0.46) | F2PRSS1PRSS2PRSS3CMA1 | |
| SCHEMBL9075674 | 0.91 | F2 (0.51) | F2PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL9076469 | 0.91 | F2 (0.51) | F2PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL7341166 | 0.90 | F2 (0.53) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7338554 | 0.90 | F2 (0.53) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL20872338 | 0.89 | F2 (0.45) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | claimed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | claimed |
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |