Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.80 |
| ▸ | DRD4 | P21917 | 10/20 | 0.80 |
| ▸ | DRD3 | P35462 | 10/20 | 0.80 |
| ▸ | HTR6 | P50406 | 4/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14507278 | 0.91 | DRD2 (0.65) | DRD2DRD4DRD3HTR6 | |
| SCHEMBL7332955 | 0.89 | DRD4 (1.00) | DRD2DRD4DRD3HTR6 | |
| SCHEMBL7334823 | 0.88 | DRD2 (0.80) | DRD2DRD4DRD3HTR6ADRB3 | |
| SCHEMBL8344029 | 0.86 | DRD2 (0.80) | DRD2DRD4DRD3HTR6 | |
| SCHEMBL7340033 | 0.85 | DRD2 (0.93) | DRD2DRD4DRD3HTR6BRAF | |
| SCHEMBL7339432 | 0.85 | DRD2 (0.75) | DRD2DRD4DRD3HTR6ADRB3 | |
| SCHEMBL7341090 | 0.80 | DRD4 (1.00) | DRD2DRD4DRD3HTR6 | |
| SCHEMBL7339411 | 0.79 | DRD4 (0.81) | DRD2DRD4DRD3HTR6 | |
| SCHEMBL7341397 | 0.78 | DRD2 (0.67) | DRD2DRD4DRD3HTR6ADRB3 | |
| SCHEMBL7337922 | 0.77 | DRD2 (0.69) | DRD2DRD4DRD3HTR6BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | claimed |
| US-6103744-A | ADMINISTERING TO THE PATIENT A DOPAMINE AUTORECEPTOR AGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA, PARKINSON,S DISEASE, TOURETTE,S SYNDROM, ALCOHOLISM AND DRUG ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |