Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TNKS | O95271 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GPR3 | P46089 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342186 | 0.88 | PARP1 (0.54) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8819543 | 0.87 | PARP1 (0.53) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL27918352 | 0.86 | PARP1 (0.77) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL4231006 | 0.84 | GAA (0.67) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL29204435 | 0.84 | PARP1 (0.64) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL13833009 | 0.84 | KDM4E (0.67) | KDM4EKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3224273 | 0.82 | PARP1 (0.75) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL14598929 | 0.81 | KDM4E (0.62) | KDM4EKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL20227580 | 0.80 | PARP1 (0.67) | PARP1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL14355035 | 0.80 | PARP1 (0.62) | PARP1KDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| WO-1996022282-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |