Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | FRK | P42685 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | STK3 | Q13188 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8819543 | 0.98 | PARP1 (0.53) | PARP1KDM4ECSF1RCA1CA2 | |
| SCHEMBL29204435 | 0.89 | PARP1 (0.64) | PARP1KDM4ECSF1RROCK2MAP4K4 | |
| SCHEMBL7334274 | 0.88 | PARP1 (0.57) | PARP1KDM4ECSF1RROCK2MAP4K4 | |
| SCHEMBL13833009 | 0.86 | KDM4E (0.67) | KDM4ECA1CA2CDK2CAMK2B | |
| SCHEMBL31490922 | 0.83 | LMNA (0.60) | PARP1KDM4ECA1CA2MEN1 | |
| SCHEMBL14598929 | 0.83 | KDM4E (0.62) | KDM4ECA1CA2CDK2CAMK2B | |
| SCHEMBL20227580 | 0.82 | PARP1 (0.67) | PARP1KDM4ECSF1RROCK2MAP4K4 | |
| SCHEMBL13377739 | 0.81 | MEN1 (0.50) | PARP1KDM4ECSF1RCA1CA2 | |
| SCHEMBL14355035 | 0.81 | PARP1 (0.62) | PARP1KDM4ECSF1RROCK2MAP4K4 | |
| SCHEMBL27918352 | 0.81 | PARP1 (0.77) | PARP1KDM4ECSF1RROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5246996-A | — | — | None | — | — | JP | disclosed |
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0544168-B1 | Use of aminoalkyl substituted 5,6-dihydro-dibenzo(b,e)azepin-6,11-dion-11-oximes as antiviral agents | BAYER AG (DE) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996022282-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5416209-A | REVERSE TRANSCRIPTASE INHIBITORS; ANTIRETROVIRAL AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1995-05-16 | — | — | US | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5385899-A | Antiretroviral agents | BAYER AKTIENGESELLSCHAFT (DE) | 1995-01-31 | — | — | US | disclosed |
| EP-0544171-B1 | Use of 5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes for the preparation of antiretroviral agents. | BAYER AG (DE) | 1994-11-17 | — | — | EP | disclosed |
| JP-H05246996-A | 5,6-DIHYDRO-BENZ(B,E)AZEPINE-6,11-DIONE-11-OXIMES | BAYER AG | 1993-09-24 | — | — | JP | disclosed |
| EP-0544168-A1 | Aminoalkyl substituted 5,6-dihydro-dibenzo(b,e)azepin-6,11-dion-11-oximes | BAYER AG (DE) | 1993-06-02 | — | — | EP | disclosed |
| EP-0544171-A1 | Use of 5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes for the preparation of antiretroviral agents. | BAYER AG (DE) | 1993-06-02 | — | — | EP | disclosed |