Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | PRKX | P51817 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334336 | 1.00 | ROCK2 (0.53) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL7325366 | 0.85 | ROCK2 (0.60) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL7325357 | 0.85 | ROCK2 (0.60) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| Hydrochloric Acid SCHEMBL6243863 | 0.81 | ROCK2 (0.51) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL1554084 | 0.81 | GLA (0.63) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL1554086 | 0.81 | GLA (0.63) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL26776040 | 0.81 | ROCK2 (0.65) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL1553309 | 0.79 | GLA (0.60) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL1553306 | 0.79 | GLA (0.60) | ROCK2ROCK1PKN2TP53RPS6KA5 | |
| SCHEMBL7328535 | 0.79 | GLA (0.54) | ROCK2ROCK1PKN2TP53RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370498-A2 | Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |