Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.58 |
| ▸ | EDNRB | P24530 | 8/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339367 | 0.89 | EDNRA (0.75) | EDNRAEDNRBAGTR1 | |
| SCHEMBL8903655 | 0.87 | EDNRA (0.61) | EDNRAEDNRBAGTR1TSHRUSP2 | |
| SCHEMBL7338422 | 0.87 | EDNRA (0.60) | EDNRAEDNRBAGTR1TSHRUSP2 | |
| SCHEMBL7332725 | 0.84 | EDNRA (0.58) | EDNRAEDNRBAGTR1TSHRALDH1A1 | |
| SCHEMBL7339641 | 0.83 | EDNRA (0.55) | EDNRAEDNRBAGTR1TSHRUSP2 | |
| SCHEMBL8906313 | 0.80 | EDNRA (0.64) | EDNRAEDNRBAGTR1TSHR | |
| SCHEMBL7332065 | 0.79 | EDNRA (0.63) | EDNRAEDNRBAGTR1TSHRALDH1A1 | |
| SCHEMBL7338516 | 0.79 | EDNRA (0.53) | EDNRAEDNRBAGTR1 | |
| SCHEMBL7338352 | 0.78 | EDNRA (0.45) | EDNRAEDNRBAGTR1TSHRUSP2 | |
| SCHEMBL7332942 | 0.78 | EDNRA (0.52) | EDNRAEDNRBAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |