Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334516 | 0.78 | EDNRA (0.58) | EDNRAEDNRBTSHRLMNAALDH1A1 | |
| SCHEMBL8788232 | 0.77 | EDNRA (0.42) | EDNRAEDNRBTSHRKDM4EMEN1 | |
| SCHEMBL7340508 | 0.77 | SMN1; SMN2 (0.39) | EDNRAEDNRBKDM4ENPC1RAB9A | |
| SCHEMBL7339367 | 0.76 | EDNRA (0.75) | EDNRAEDNRBAGTR1 | |
| Potassium Ion SCHEMBL7336271 | 0.74 | EDNRA (0.59) | EDNRAEDNRBAGTR1 | |
| SCHEMBL7330512 | 0.74 | EDNRA (0.59) | EDNRAEDNRBAGTR1 | |
| SCHEMBL23515193 | 0.69 | EDNRB (0.47) | EDNRAEDNRBTSHRKDM4ENPC1 | |
| SCHEMBL8906313 | 0.67 | EDNRA (0.64) | EDNRAEDNRBTSHRMEN1KMT2A | |
| SCHEMBL7338764 | 0.67 | EDNRA (0.84) | EDNRAEDNRBLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7332065 | 0.66 | EDNRA (0.63) | EDNRAEDNRBTSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |