Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332442 | 0.89 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL6755365 | 0.86 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364183 | 0.85 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364186 | 0.85 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8691670 | 0.85 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8688514 | 0.81 | PDE4A (0.68) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8688513 | 0.80 | PDE4A (0.68) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7361500 | 0.80 | PDE4A (0.70) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7361501 | 0.80 | PDE4A (0.70) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7321974 | 0.79 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | claimed |
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | disclosed |