Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361500 | 1.00 | PDE4A (0.70) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364186 | 0.94 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364183 | 0.94 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7394569 | 0.86 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6755269 | 0.86 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7359401 | 0.86 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7359404 | 0.86 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387378 | 0.83 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387380 | 0.83 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387472 | 0.83 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | claimed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | disclosed |