Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.43 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.43 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.43 |
| ▸ | ACE | P12821 | 10/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321705 | 1.00 | TPSAB1 (0.43) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7334676 | 1.00 | TPSAB1 (0.43) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7321716 | 1.00 | TPSAB1 (0.43) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7333437 | 0.99 | ACE (0.43) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7333454 | 0.99 | ACE (0.43) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7334538 | 0.95 | ACE (0.44) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7334547 | 0.95 | ACE (0.44) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7324664 | 0.91 | ACE (0.46) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7324677 | 0.91 | ACE (0.46) | TPSAB1TPSD1TPSG1ACEMME | |
| SCHEMBL7326265 | 0.83 | TPSAB1 (0.42) | TPSAB1TPSD1TPSG1ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4598071-A | ANGIOTENSIN INHIBITORS/ | E. R. SQUIBB & SONS, INC. (US) | 1986-07-01 | — | — | US | disclosed |
| US-4567167-A | INHIBITOR OF ANGIOTENDIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4533661-A | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | disclosed |