Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408359 | 0.92 | NPC1 (0.56) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL11545573 | 0.91 | NPC1 (0.61) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL11545932 | 0.91 | NPC1 (0.61) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL11545921 | 0.89 | NPC1 (0.68) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL11539115 | 0.86 | NPC1 (0.56) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL1942075 | 0.84 | NPC1 (0.77) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL248876 | 0.84 | NPC1 (0.53) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL215008 | 0.83 | NPC1 (0.56) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL8052779 | 0.83 | NPC1 (0.56) | NPC1RAB9ARECQLKDM4EMAPT | |
| SCHEMBL30967467 | 0.83 | NPC1 (0.56) | NPC1RAB9ARECQLKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1138761-C | 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and use as dopamine autoreceptor (D2) agonists | — | 2004-02-18 | — | — | CN | disclosed |
| US-6127380-A | A D2 DOPAMINERGIC AGENT FOR THE TREATMENT OF SCHIZOPHRENIA, PARKINSON'S DISEASE, TOURETTE'S SYNDROME, AND DRUG OR ALCOHOL ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6103744-A | ADMINISTERING TO THE PATIENT A DOPAMINE AUTORECEPTOR AGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA, PARKINSON,S DISEASE, TOURETTE,S SYNDROM, ALCOHOLISM AND DRUG ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| CN-1252793-A | 4-aminoalkoxy-1H-benzimidazole derivatives, their preparation and their use as dopamine autoreceptor D2 agonists | AMERICAN HOME PROD (US) | 2000-05-10 | — | — | CN | disclosed |
| CN-1252060-A | 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and use as dopamine autoreceptor (D2) agonists | AMERICAN HOME PROD (US) | 2000-05-03 | — | — | CN | disclosed |
| CN-1252061-A | 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-thiones derivatives, their preparation and use as dopamine autoreceptor (D2) agonists | AMERICAN HOME PROD (US) | 2000-05-03 | — | — | CN | disclosed |
| EP-0973749-A1 | 4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| EP-0964853-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0964854-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| US-5972958-A | 4-aminoalkoxy-1,3-dihydro-benzoimidazol-2-thiones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998035946-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998035945-A1 | 4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998035947-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |