Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.50 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | VNN1 | O95497 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491515 | 0.88 | FFAR1 (0.72) | FFAR1FFAR4CNR1LMNAPLA2G10 | |
| SCHEMBL934610 | 0.86 | FFAR1 (0.55) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL2411845 | 0.86 | FFAR1 (0.55) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL6364918 | 0.86 | FFAR1 (0.55) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL7421178 | 0.84 | FFAR1 (0.50) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL27322168 | 0.83 | FFAR1 (0.52) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL2154019 | 0.82 | GLA (0.53) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL3926844 | 0.82 | FFAR1 (0.54) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL3109008 | 0.82 | FFAR1 (0.54) | FFAR1FFAR4CNR1MEP1AMEP1B | |
| SCHEMBL7055202 | 0.82 | FFAR1 (0.51) | FFAR1FFAR4CNR1MEP1AMEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |