Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336005 | 1.00 | POLB (0.50) | POLBSMN1; SMN2PKMHTTCYP1A2 | |
| SCHEMBL3120355 | 0.83 | SMN1; SMN2 (0.64) | POLBSMN1; SMN2PKMHTTCYP1A2 | |
| SCHEMBL13127984 | 0.82 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2PKMHTTCYP1A2 | |
| SCHEMBL7339063 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2PKMHTTCYP1A2CYP2C9 | |
| SCHEMBL9275745 | 0.81 | CYP1A2 (0.46) | POLBSMN1; SMN2PKMHTTCYP1A2 | |
| SCHEMBL8658788 | 0.81 | SMN1; SMN2 (0.68) | POLBSMN1; SMN2PKMHTTCYP2C9 | |
| Alanine SCHEMBL27702303 | 0.81 | SMN1; SMN2 (0.53) | POLBSMN1; SMN2PKMHTTCYP1A2 | |
| SCHEMBL7339055 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2PKMHTTCYP1A2CYP2C9 | |
| SCHEMBL10590434 | 0.81 | SMN1; SMN2 (0.68) | POLBSMN1; SMN2PKMHTTCYP2C9 | |
| SCHEMBL6467989 | 0.81 | SMN1; SMN2 (0.68) | POLBSMN1; SMN2PKMHTTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |