Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339063 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1PKMCCR1MEN1 | |
| SCHEMBL15429735 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1PKMCCR1MEN1 | |
| SCHEMBL21898096 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1PKMCCR1MEN1 | |
| SCHEMBL5711205 | 0.84 | KDM4E (0.43) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL6447920 | 0.84 | KDM4E (0.43) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL15429750 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1PKMCCR1MEN1 | |
| SCHEMBL15429942 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1PKMCCR1MEN1 | |
| SCHEMBL8346050 | 0.83 | KMT2A (0.57) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL7345198 | 0.83 | KMT2A (0.57) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL7345195 | 0.83 | KMT2A (0.57) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | disclosed |