Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405457 | 1.00 | KDM4E (0.53) | KDM4ESMN1; SMN2KMT2AALDH1A1HPGD | |
| SCHEMBL5950255 | 0.83 | KDM4E (0.73) | KDM4ESMN1; SMN2KMT2AALDH1A1POLB | |
| SCHEMBL6534174 | 0.83 | KDM4E (0.73) | KDM4ESMN1; SMN2KMT2AALDH1A1POLB | |
| SCHEMBL7670891 | 0.77 | KDM4E (0.69) | KDM4ESMN1; SMN2KMT2AALDH1A1POLB | |
| SCHEMBL7837671 | 0.77 | KDM4E (0.69) | KDM4ESMN1; SMN2KMT2AALDH1A1POLB | |
| SCHEMBL6512359 | 0.72 | ACE (0.50) | — | |
| SCHEMBL2194754 | 0.72 | ACE (0.50) | — | |
| SCHEMBL21874335 | 0.71 | ACE (0.49) | — | |
| SCHEMBL27957044 | 0.71 | ACE (0.49) | — | |
| SCHEMBL3791081 | 0.71 | ACE (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242468-B1 | Carbamate and urea compositions and neurotrophic uses | GLIAMED, INC. | 2001-06-05 | — | — | US | claimed |
| US-6395758-B1 | VISION DEFECTS | GPI NIL HOLDINGS, INC. | 2002-05-28 | — | — | US | disclosed |
| EP-1107757-A2 | CARBAMATE AND UREA COMPOSITIONS AND NEUROTROPHIC USES | GUILFORD PHARMACEUTICALS INC. (US) | 2001-06-20 | — | — | EP | disclosed |
| US-6242468-B1 | Carbamate and urea compositions and neurotrophic uses | GLIAMED, INC. | 2001-06-05 | — | — | US | disclosed |
| US-6194440-B1 | Small molecule carbamate or urea hair growth compositions and uses | GPI NIL HOLDINGS, INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-2000010553-A2 | CARBAMATE AND UREA COMPOSITIONS AND NEUROTROPHIC USES | GPI NIL HOLDINGS, INC. (US) | 2000-03-02 | — | — | WO | disclosed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | disclosed |