Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670891 | 1.00 | KDM4E (0.69) | KDM4ESMN1; SMN2POLBTSHRNPSR1 | |
| SCHEMBL5950255 | 0.87 | KDM4E (0.73) | KDM4ESMN1; SMN2POLBTSHRNPSR1 | |
| SCHEMBL6534174 | 0.87 | KDM4E (0.73) | KDM4ESMN1; SMN2POLBTSHRNPSR1 | |
| SCHEMBL7837668 | 0.82 | KDM4E (0.71) | KDM4ESMN1; SMN2POLBTSHRNPSR1 | |
| SCHEMBL7670889 | 0.82 | KDM4E (0.71) | KDM4ESMN1; SMN2POLBTSHRNPSR1 | |
| SCHEMBL7405457 | 0.77 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBNPSR1ALDH1A1 | |
| SCHEMBL7336982 | 0.77 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBNPSR1ALDH1A1 | |
| SCHEMBL7677220 | 0.75 | KDM4E (0.40) | KDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7680333 | 0.75 | LMNA (0.46) | KDM4ESMN1; SMN2POLBALDH1A1KMT2A | |
| SCHEMBL18051877 | 0.75 | KDM4E (0.61) | KDM4ESMN1; SMN2POLBTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959882-A4 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | HAMILTON GREGORY S (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0959882-A1 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998029117-A1 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-07-09 | — | — | WO | disclosed |