Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 5/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959919 | 1.00 | SLC5A2 (0.61) | SLC5A2CA2NAMPTCYP2A6ADRB2 | |
| SCHEMBL1539306 | 0.87 | SLC5A2 (0.55) | SLC5A2NAMPTCYP2A6ADRB2SMN1; SMN2 | |
| SCHEMBL6958014 | 0.85 | TUBB4A (0.53) | SLC5A2CYP2A6ADRB2AGXTASIC3 | |
| SCHEMBL7086153 | 0.82 | CYP2A6 (0.53) | SLC5A2CYP2A6ADRB2NPC1RAB9A | |
| SCHEMBL7819877 | 0.79 | CYP2A6 (0.50) | SLC5A2CYP2A6ADRB2AGXTASIC3 | |
| SCHEMBL7339450 | 0.79 | SLC5A2 (0.55) | SLC5A2CYP2A6ADRB2AGXTASIC3 | |
| SCHEMBL6964522 | 0.79 | SLC5A2 (0.55) | SLC5A2CYP2A6ADRB2AGXTASIC3 | |
| SCHEMBL12257578 | 0.78 | SLC5A2 (0.71) | SLC5A2 | |
| SCHEMBL1854869 | 0.78 | SLC5A2 (0.47) | SLC5A2NAMPTCYP2A6ADRB2AGXT | |
| SCHEMBL2201493 | 0.78 | SLC5A2 (1.00) | SLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |