Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.39 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | GBA1 known ✓ | P04062 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL282045 | 0.97 | TSHR (0.67) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Tartaric Acid SCHEMBL30771976 | 0.97 | TSHR (0.67) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Cadaverine Tartrate SCHEMBL27681736 | 0.94 | TSHR (0.62) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Cadaverine Tartrate SCHEMBL27981116 | 0.94 | TSHR (0.62) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Cadaverine Tartrate SCHEMBL27681738 | 0.94 | TSHR (0.62) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Cadaverine Tartrate SCHEMBL6560274 | 0.91 | TSHR (0.59) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Cadaverine Tartrate SCHEMBL18987140 | 0.87 | TSHR (0.71) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Cadaverine Tartrate SCHEMBL27525534 | 0.84 | TSHR (0.67) | TSHROR51E2CYP2C9PDE4ATP53 | |
| Cadaverine Tartrate SCHEMBL2158124 | 0.84 | TSHR (0.67) | TSHRCYP2C9PDE4ATP53CHRM1 | |
| Cadaverine Tartrate SCHEMBL905466 | 0.83 | TSHR (0.91) | TSHROR51E2CYP2C9PDE4ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741724-B1 | NEUROPROTECTIVE CHROMAN COMPOUNDS | PFIZER (US) | 1999-08-11 | — | — | EP | claimed |
| EP-0741724-A1 | NEUROPROTECTIVE CHROMAN COMPOUNDS | PFIZER INC. (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020587-A1 | NEUROPROTECTIVE CHROMAN COMPOUNDS | PFIZER INC. (US) | 1995-08-03 | — | — | WO | disclosed |