SCHEMBL7337185

SCHEMBL7337185

OCCC1CCCN(Cc2ccccc2)C1

nearest known ligand 0.66

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.66
ALDH1A1 P00352 2/20 0.63
CYP1A2 P05177 1/20 0.59
CYP3A4 P08684 1/20 0.59
CYP2C19 P33261 1/20 0.59
BCHE P06276 4/20 0.55
ACHE P22303 2/20 0.55
MAOB P27338 1/20 0.55
SIGMAR1 Q99720 2/20 0.54
KDM4E B2RXH2 1/20 0.51
HPGD P15428 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6823142 0.91 CCR3 (0.58) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL8340597 0.91 CCR3 (0.58) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL12611607 0.88 CCR3 (0.59) CYP2D6ALDH1A1BCHEACHE
SCHEMBL7071972 0.88 CYP2D6 (0.83) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL1944588 0.88 CYP2D6 (0.83) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL21812109 0.86 CTSS (0.61) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL11199596 0.86 CYP2D6 (0.60) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL9598912 0.86 CTSS (0.61) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL7514732 0.85 CYP2D6 (0.59) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL12513821 0.85 CYP2D6 (0.59) CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002030897-A2 COMPOSITIONS AND METHODS FOR REGULATING THE NERVOUS SYSTEM FILLION GILLES (FR) 2002-04-18 WO disclosed
EP-0705258-B1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY KNOLL AG (DE) 1998-12-30 EP disclosed
US-5741800-A ANTIINFLAMMATORY AGENT, ANTIALLERGENS KNOLL AKTIENGESELLACHAFT (DE) 1998-04-21 US disclosed
EP-0705258-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY Knoll AG (DE) 1996-04-10 EP disclosed
WO-1995000507-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY KNOLL AG (DE) 1995-01-05 WO disclosed
US-5290789-A Antipsychotically effective compounds STERLING WINTROP INC. (US) 1994-03-01 US disclosed
US-5175157-A Cardiovascular disorders BOEHRINGER INGELHEIM GMBH (DE) 1992-12-29 US disclosed