Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573518 | 0.89 | PDE3B (0.52) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL7327893 | 0.87 | PDE3B (0.52) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL4888905 | 0.84 | PDE3B (0.52) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL7336619 | 0.84 | LMNA (0.72) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL8191155 | 0.83 | PDE3B (0.61) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL4890576 | 0.82 | PDE3B (0.54) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL4903296 | 0.80 | PDE3B (0.54) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL7337183 | 0.80 | PDE3B (0.49) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL8266841 | 0.79 | PDE3B (0.53) | LMNANPY1RNPY2RPDE4BPDE3B | |
| SCHEMBL7333826 | 0.79 | TP53 (0.47) | LMNANPY1RNPY2RPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |