Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.64 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.62 |
| ▸ | TACR1 | P25103 | 3/20 | 0.59 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 3/20 | 0.55 |
| ▸ | CTSK | P43235 | 4/20 | 0.54 |
| ▸ | CTSL | P07711 | 3/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736218 | 1.00 | TRPM8 (0.64) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL5916913 | 1.00 | TRPM8 (0.64) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL4949767 | 1.00 | TRPM8 (0.64) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL2736202 | 1.00 | TRPM8 (0.64) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL9421829 | 1.00 | TRPM8 (0.64) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL15241328 | 0.92 | TRPM8 (0.56) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL12249402 | 0.92 | TRPM8 (0.59) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL7221074 | 0.92 | TRPM8 (0.56) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL12249357 | 0.92 | TRPM8 (0.59) | TRPM8CTRB1TACR1CTSDCTSB | |
| SCHEMBL6925966 | 0.92 | TRPM8 (0.56) | TRPM8CTRB1TACR1CTSDCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5942632-A | NOVEL 4,5-BIS(PROTECTED-AMINO), 2-(PROTECTED-CARBOXY)-1,3-DIOXOLANE COMPOUNDS THAT CAN BE USED TO PREPARE HIV PROTEASE INHIBITORS BY COUPLING TO A SOLID SUPPORT VIA AN ESTER OR AN AMIDE LINKAGE | ABBOTT LABORATORIES (US) | 1999-08-24 | — | — | US | disclosed |
| US-5877334-A | OF PROTEASE INHIBITOR | ABBOTT LABORATORIES (US) | 1999-03-02 | — | — | US | disclosed |
| US-5837873-A | PROTECTED OXYDIAMINES | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5616714-A | PYRIDYL, THIAZOLYL-SUBSTITUTED AMINO ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1993023361-A1 | PROCESS FOR THE PREPARATION OF A SUBSTITUTED DIAMINODIOL | ABBOTT LABORATORIES (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |