Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.51 |
| ▸ | PDE8A | O60658 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | PDE9A | O76083 | 1/20 | 0.51 |
| ▸ | PDE8B | O95263 | 1/20 | 0.51 |
| ▸ | PDE6A | P16499 | 1/20 | 0.51 |
| ▸ | PDE6G | P18545 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE6B | P35913 | 1/20 | 0.51 |
| ▸ | PDE6C | P51160 | 1/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.51 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337859 | 0.84 | PDE3B (0.50) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL8314487 | 0.78 | PDE2A (0.50) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL1387892 | 0.77 | PDE2A (0.49) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL1387425 | 0.75 | PDE2A (0.48) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL7409642 | 0.73 | — | — | |
| SCHEMBL7845913 | 0.72 | PDE2A (0.45) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL7845909 | 0.72 | PDE2A (0.45) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL31377420 | 0.71 | PARP1 (0.57) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL11638724 | 0.71 | PDE3B (0.56) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL30273078 | 0.70 | PDE2A (0.69) | PDE3BPDE3APDE2APDE6DPDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | claimed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | claimed |
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |