Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | PDE6D | O43924 | 1/20 | 0.50 |
| ▸ | PDE8A | O60658 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | PDE9A | O76083 | 1/20 | 0.50 |
| ▸ | PDE8B | O95263 | 1/20 | 0.50 |
| ▸ | PDE6A | P16499 | 1/20 | 0.50 |
| ▸ | PDE6G | P18545 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE6B | P35913 | 1/20 | 0.50 |
| ▸ | PDE6C | P51160 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.50 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387892 | 0.87 | PDE2A (0.49) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL1387425 | 0.86 | PDE2A (0.48) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL8316653 | 0.82 | GRIN2D (0.42) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL7845909 | 0.82 | PDE2A (0.45) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL7845913 | 0.82 | PDE2A (0.45) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL1387392 | 0.79 | — | — | |
| SCHEMBL7337362 | 0.78 | PDE3B (0.51) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL7413560 | 0.74 | PDE2A (0.48) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL8314287 | 0.74 | MAPK8 (0.46) | — | |
| SCHEMBL7415664 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708774-B1 | IMIDAZO[1,2-a]PYRAZIN-4-ONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | claimed |
| EP-0752991-B1 | IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-05-26 | — | — | EP | disclosed |
| EP-0708774-B1 | IMIDAZO[1,2-a]PYRAZIN-4-ONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | disclosed |
| EP-0708774-A1 | IMIDAZO [1,2-A]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002601-A1 | IMIDAZO[1,2-a]PYRAZINE-4-ONE, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-01-26 | — | — | WO | disclosed |