Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29065724 | 0.83 | IDO1 (0.48) | IDO1GSK3AGSK3BCA12CA1 | |
| SCHEMBL9075896 | 0.82 | TAAR1 (0.53) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL9384544 | 0.81 | IDO1 (0.50) | IDO1GSK3AGSK3BCA12CA1 | |
| SCHEMBL5305930 | 0.81 | IDO1 (0.50) | IDO1GSK3AGSK3BCA12CA1 | |
| SCHEMBL5574984 | 0.80 | IDO1 (0.54) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL297636 | 0.78 | IDO1 (0.52) | IDO1GSK3AGSK3BCA12CA1 | |
| SCHEMBL9615514 | 0.77 | IDO1 (0.50) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL7333275 | 0.76 | IDO1 (0.42) | IDO1ALDH1A1MAPTAGXTTAAR1 | |
| SCHEMBL7337431 | 0.76 | MGLL (0.42) | CA2ALDH1A1TAAR1SMN1; SMN2ATM | |
| SCHEMBL7338557 | 0.76 | IDO1 (0.42) | IDO1ALDH1A1KDM4EMAPTAGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1216921-A | Method for inducing vascular cell adhesion molecule-1 and treating chronic inflammatory diseases using 2, 6-dialkyl-4-silyl-phenols | HOECHST MARION ROUSSEL INC (US) | 1999-05-19 | — | — | CN | disclosed |
| EP-0910384-A1 | METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-28 | — | — | EP | disclosed |
| US-5795876-A | ANTIINFLAMMATORY AGENTS | HOECHST MARION ROUSSSEL, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| WO-1997040837-A1 | METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-06 | — | — | WO | disclosed |
| EP-0468825-B1 | Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same | RICHTER GEDEON VEGYESZET (HU) | 1997-01-08 | — | — | EP | disclosed |
| US-5340823-A | Administering a muscle relaxants for treating parkinson*s disease | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1994-08-23 | — | — | US | disclosed |
| US-5198446-A | Muscle Relaxants | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1993-03-30 | — | — | US | disclosed |
| EP-0468825-A1 | Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1992-01-29 | — | — | EP | disclosed |