Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 6/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962653 | 1.00 | PTPN1 (0.49) | PTPN1CNR2CNR1LOXL2CD274 | |
| SCHEMBL7344806 | 0.91 | CNR2 (0.46) | PTPN1CNR2CNR1LOXL2CD274 | |
| SCHEMBL6957898 | 0.91 | CNR2 (0.46) | PTPN1CNR2CNR1LOXL2CD274 | |
| SCHEMBL7334824 | 0.84 | CNR2 (0.43) | PTPN1CNR2CNR1LOXL2CD274 | |
| SCHEMBL6954391 | 0.84 | CNR2 (0.43) | PTPN1CNR2CNR1LOXL2CD274 | |
| SCHEMBL6954916 | 0.77 | TP53 (0.45) | PTPN1CNR2CNR1LOXL2MAPT | |
| SCHEMBL7336814 | 0.77 | TP53 (0.45) | PTPN1CNR2CNR1LOXL2MAPT | |
| SCHEMBL13179819 | 0.76 | LOXL2 (0.61) | PTPN1CNR2CNR1LOXL2CD274 | |
| SCHEMBL6788010 | 0.76 | CNR2 (0.46) | PTPN1CNR2CNR1LOXL2L3MBTL1 | |
| SCHEMBL6957346 | 0.76 | PTPN1 (0.41) | PTPN1LOXL2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |