Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329786 | 0.83 | ELANE (0.54) | ELANEPKMALDH1A1NPC1CYP1A2 | |
| SCHEMBL7328809 | 0.76 | ELANE (0.53) | ELANEPKMALDH1A1POLB | |
| SCHEMBL7339814 | 0.74 | ELANE (0.53) | ELANEPKMALDH1A1POLB | |
| SCHEMBL7337980 | 0.72 | NPSR1 (0.36) | ELANEALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL7330895 | 0.72 | ELANE (0.54) | ELANEPKMALDH1A1POLB | |
| SCHEMBL8600680 | 0.72 | ALDH1A1 (0.51) | ELANEPKMALDH1A1NPC1CYP1A2 | |
| SCHEMBL7416331 | 0.71 | ELANE (1.00) | ELANE | |
| SCHEMBL7310549 | 0.70 | ELANE (1.00) | ELANEPKMALDH1A1 | |
| SCHEMBL7329890 | 0.69 | KDM4E (0.46) | ELANEPKMALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7420488 | 0.69 | ELANE (1.00) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793494-A4 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0793494-A1 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016649-A1 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| US-5494925-A | TREATING DEGENERATIVE DISORDERS; PROTEOLYTIC ENZYME INHIBITOR | STERLING WINTHROP INC. (US) | 1996-02-27 | — | — | US | disclosed |