Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 2/20 | 0.54 |
| ▸ | ELANE | P08246 | 17/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332864 | 0.88 | C1R (0.53) | C1RELANE | |
| SCHEMBL7333602 | 0.83 | ELANE (0.66) | C1RELANE | |
| SCHEMBL10362993 | 0.80 | ELANE (0.64) | C1RELANECTRB1 | |
| SCHEMBL7331779 | 0.79 | C1R (0.55) | C1RELANE | |
| SCHEMBL7332215 | 0.79 | MAPT (0.58) | C1RELANE | |
| SCHEMBL7364114 | 0.77 | ELANE (0.67) | C1RELANE | |
| SCHEMBL7332212 | 0.76 | C1R (0.53) | C1RELANE | |
| SCHEMBL7333524 | 0.76 | C1R (0.54) | C1RELANE | |
| SCHEMBL7332663 | 0.76 | C1R (0.51) | C1RELANE | |
| SCHEMBL7364248 | 0.74 | ELANE (0.47) | C1RELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |