Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | C1R | P00736 | 6/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333376 | 0.90 | ELANE (0.54) | ELANEALDH1A1KDM4EGAAC1R | |
| SCHEMBL7333378 | 0.89 | ELANE (0.50) | ELANEALDH1A1KDM4EC1RPRSS1 | |
| SCHEMBL7329441 | 0.89 | ELANE (0.63) | ELANEC1RPRSS1 | |
| SCHEMBL7337855 | 0.88 | ELANE (0.48) | ELANEALDH1A1KDM4EC1RPRSS1 | |
| SCHEMBL7333539 | 0.85 | ELANE (0.74) | ELANEC1RPRSS1 | |
| SCHEMBL7338602 | 0.84 | ELANE (0.51) | ELANEALDH1A1KDM4EXBP1GAA | |
| SCHEMBL7363986 | 0.82 | ELANE (0.66) | ELANEC1RPRSS1 | |
| SCHEMBL7332655 | 0.81 | ELANE (0.59) | ELANEC1RPRSS1 | |
| SCHEMBL7331994 | 0.81 | ELANE (0.53) | ELANEALDH1A1KDM4EC1RPRSS1 | |
| SCHEMBL7330994 | 0.80 | ELANE (0.51) | ELANEALDH1A1KDM4EC1RPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | claimed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | claimed |
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |