Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.51 |
| ▸ | C1R | P00736 | 8/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330017 | 0.88 | C1R (0.48) | ELANEC1RPRSS1ALDH1A1KDM4E | |
| SCHEMBL7338722 | 0.85 | ELANE (0.54) | ELANEC1RPRSS1 | |
| SCHEMBL7338273 | 0.84 | ELANE (0.58) | ELANEC1RPRSS1ALDH1A1KDM4E | |
| SCHEMBL7340082 | 0.81 | ELANE (0.59) | ELANEC1RPRSS1 | |
| SCHEMBL7333376 | 0.79 | ELANE (0.54) | ELANEC1RPRSS1ALDH1A1KDM4E | |
| SCHEMBL7332266 | 0.77 | ELANE (0.51) | ELANEC1RPRSS1 | |
| SCHEMBL7333378 | 0.76 | ELANE (0.50) | ELANEC1RPRSS1ALDH1A1KDM4E | |
| SCHEMBL7337855 | 0.75 | ELANE (0.48) | ELANEC1RPRSS1ALDH1A1KDM4E | |
| SCHEMBL7339866 | 0.74 | ELANE (0.55) | ELANEC1RPRSS1 | |
| SCHEMBL7329441 | 0.72 | ELANE (0.63) | ELANEC1RPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | claimed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | claimed |
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |