⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27895519 | 0.69 | — | — | |
| SCHEMBL8061421 | 0.68 | MEN1 (0.31) | — | |
| SCHEMBL2301660 | 0.65 | — | — | |
| SCHEMBL8725917 | 0.65 | LMNA (0.30) | — | |
| SCHEMBL1065872 | 0.64 | TSHR (0.30) | — | |
| SCHEMBL18965297 | 0.64 | MEN1 (0.33) | — | |
| SCHEMBL12731752 | 0.63 | — | — | |
| SCHEMBL6891499 | 0.62 | — | — | |
| SCHEMBL13029878 | 0.58 | — | — | |
| SCHEMBL9672704 | 0.58 | MEN1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138330-B2 | Solid phase synthesis via deblocking immobilized nucleoside, then coupling acyl protected nucleoside phosphoramidite | SIGMA-ALDRICH CO. LLC (US) | 2012-03-20 | — | — | US | disclosed |
| EP-0710667-B1 | Modified oligonucleotides, their preparation and their use | ROCHE DIAGNOSTICS GMBH (DE) | 2011-12-14 | — | — | EP | disclosed |
| US-7566775-B2 | N8- and C8-linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotides hybridization | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| EP-1301523-B1 | N8 - AND C8 -LINKED PURINE BASES AND STRUCTURALLY RELATED HETEROCYCLES AS UNIVERSAL NUCLEOSIDES USED FOR OLIGONUCLEOTIDE HYBRIDIZATION | ROCHE DIAGNOSTICS GMBH (DE) | 2009-01-14 | — | — | EP | disclosed |
| US-20080064867-A1 | PROCESS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES | SIGMA ALDRICH COMPANY (US) | 2008-03-13 | — | — | US | disclosed |
| US-20080038745-A1 | NUCLEOTIDE ANALOGS WITH SIX-MEMBERED RINGS | BERGMANN FRANK | 2008-02-14 | — | — | US | disclosed |
| EP-1307469-B1 | NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO¬3,4-D PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES | ROCHE DIAGNOSTICS GMBH (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-20060135462-A1 | N8- and C8-linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotides hybridization | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2006-06-22 | — | — | US | disclosed |
| US-7063945-B2 | N8 -and c8 -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization | ROCHE MOLECULAR SYSTEMS, INC (US) | 2006-06-20 | — | — | US | disclosed |
| US-6987177-B2 | Modified oligonucleotides, their preparation and their use | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-01-17 | — | — | US | disclosed |
| EP-1138689-A1 | N8- and C8-linked purine bases as universal nucleosides used for oligonucleotide hybridization | Roche Diagnostics GmbH (DE) | 2001-10-04 | — | — | EP | disclosed |
| US-6150510-A | NUCLEOTIDES/NUCLEOSIDES WITH SUBSTITUTED 7-DEAZAPURINE BASE FORM MORE STABLE HYBRIDIZATION COMPLEXES; GENETIC PROBES; ANTISENSE AGENTS; GENE EXPRESSION INHIBITION; DIAGNOSTIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-21 | — | — | US | disclosed |
| US-6147199-A | 2-deoxy-isoguanosines isoteric analogues and isoguanosine containing oligonucleotides | BOEHRINGER MANNHEIM (DE) | 2000-11-14 | — | — | US | disclosed |
| US-5844106-A | Modified oligonucleotides, their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-01 | — | — | US | disclosed |
| US-5789562-A | STABLE HYBRIDIZATION COMPLEXES WITH NUCLEI ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-04 | — | — | US | disclosed |
| US-5756704-A | Nucleosides and nucleoside derivatives containing enzymatically cleavable protecting groups | BOEHRINGER MANNHEIM GMBH (DE) | 1998-05-26 | — | — | US | disclosed |
| US-5677441-A | Nucleosides, nucleotides and oligonucleotides containing enzymatically cleavable protecting groups | BOEHRINGER MANNHEIM GMBH (DE) | 1997-10-14 | — | — | US | disclosed |
| EP-0611373-B1 | OLIGO-2'-DEOXYNUCLEOTIDES AND THEIR USE AS DRUGS WITH AN ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0680969-A2 | Modified oligonucleotides, their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-08 | — | — | EP | disclosed |
| EP-0649855-A1 | Use of nucleosides and nucleoside derivatives with enzymatically cleavable protecting groupes in the synthesis of oligonucleotiden | Roche Diagnostics GmbH (DE) | 1995-04-26 | — | — | EP | disclosed |