Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733847 | 1.00 | KMT2A (0.33) | KMT2AF10SCN9AMAPK14SMN1; SMN2 | |
| SCHEMBL732289 | 0.94 | KMT2A (0.33) | KMT2AF10SCN9AMAPK14SMN1; SMN2 | |
| SCHEMBL732288 | 0.94 | KMT2A (0.33) | KMT2AF10SCN9AMAPK14SMN1; SMN2 | |
| SCHEMBL751220 | 0.92 | KMT2A (0.35) | KMT2ASCN9ASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL732786 | 0.92 | SCN9A (0.35) | KMT2AF10SCN9AMAPK14SMN1; SMN2 | |
| SCHEMBL732785 | 0.92 | SCN9A (0.35) | KMT2AF10SCN9AMAPK14SMN1; SMN2 | |
| Ethane SCHEMBL734596 | 0.92 | KMT2A (0.35) | KMT2ASCN9ASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL13513367 | 0.92 | F10 (0.32) | KMT2AF10SCN9AMAPK14SMN1; SMN2 | |
| SCHEMBL732295 | 0.92 | MAPK14 (0.36) | KMT2AF10MAPK14L3MBTL1TSHR | |
| SCHEMBL732296 | 0.92 | MAPK14 (0.36) | KMT2AF10MAPK14L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420675-B2 | Aminotetrahydroindazoloacetic acids | HOFFMANN-LA ROCHE INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-20120101131-A1 | Aminotetrahydroindazoloacetic Acids | CHEN LI (CN) | 2012-04-26 | — | — | US | disclosed |
| US-8138208-B2 | Aminotetrahydroindazoloacetic acids | HOFFMANN-LA ROCHE INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20100016369-A1 | AMINOTETRAHYDROINDAZOLOACETIC ACIDS | CHEN LI | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101131-A1 | Aminotetrahydroindazoloacetic Acids | HRH2, HRH1, HRH4 | KMT2A 2156/4885F10 736/4885SCN9A 2017/4885 |
| US-20100016369-A1 | AMINOTETRAHYDROINDAZOLOACETIC ACIDS | HRH2, HRH1, HRH4 | KMT2A 2156/4885F10 736/4885SCN9A 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.