Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972111 | 0.86 | KLK5 (0.54) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL5408855 | 0.84 | PPARG (0.57) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL5408845 | 0.84 | PPARG (0.57) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL4937975 | 0.84 | ITGB3 (0.61) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL4937967 | 0.84 | ITGB3 (0.61) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL16815979 | 0.84 | ITGB3 (0.64) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL15593763 | 0.84 | ITGB3 (0.64) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL2802881 | 0.84 | KLK5 (0.52) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL2802882 | 0.84 | KLK5 (0.52) | KLK5ITGB3ITGA2BCTSSCTSK | |
| SCHEMBL22604385 | 0.83 | GAA (0.60) | KLK5ITGB3ITGA2BCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767792-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5977101-A | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0767792-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000730-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |