Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Spirapril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 15/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spirapril SCHEMBL11052621 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL7340600 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL7338593 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL1649585 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL6506406 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL11052614 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL3785516 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL17202 | 1.00 | ABCB11 (0.98) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL387353 | 0.99 | ABCB11 (1.00) | ABCB11ACELMNASMN1; SMN2PDE3A | |
| Spirapril SCHEMBL14660503 | 0.99 | ABCB11 (1.00) | ABCB11ACELMNASMN1; SMN2PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0050800-B2 | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them | SCHERING CORP (US) | 1995-06-07 | — | — | EP | disclosed |
| US-5348944-A | Hypotensive agents | SCHERING CORPORATION (US) | 1994-09-20 | — | — | US | disclosed |
| EP-0050800-B1 | CARBOXYALKYL DIPEPTIDES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4470972-A | 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids | SCHERING CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| EP-0050800-A1 | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1982-05-05 | — | — | EP | disclosed |