Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.42 |
| ▸ | CTSE | P14091 | 4/20 | 0.39 |
| ▸ | CTSD | P07339 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PGA5 | P0DJD9 | 2/20 | 0.39 |
| ▸ | PGC | P20142 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331419 | 0.91 | AVPR1A (0.39) | ALDH1A1 | |
| SCHEMBL7331475 | 0.90 | REN (0.41) | RENCTSEKMT2A | |
| SCHEMBL7331684 | 0.88 | AVPR1A (0.37) | RENALDH1A1 | |
| SCHEMBL7333972 | 0.88 | TSHR (0.35) | RENALDH1A1 | |
| SCHEMBL7330043 | 0.85 | F2 (0.37) | REN | |
| SCHEMBL7330457 | 0.84 | REN (0.39) | RENMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7331364 | 0.84 | REN (0.48) | RENCTSECTSDMEN1ALDH1A1 | |
| SCHEMBL7339328 | 0.84 | REN (0.43) | RENCTSECTSDPGA5PGC | |
| SCHEMBL7338390 | 0.82 | REN (0.42) | RENCTSECTSDMEN1ALDH1A1 | |
| SCHEMBL7329409 | 0.78 | REN (0.42) | RENCTSECTSDMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |