Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339093 | 1.00 | NPC1 (0.37) | NPC1 | |
| SCHEMBL7338258 | 0.85 | SPHK1 (0.32) | — | |
| SCHEMBL7338254 | 0.85 | SPHK1 (0.32) | — | |
| SCHEMBL7348105 | 0.81 | NPC1 (0.38) | NPC1 | |
| SCHEMBL7337041 | 0.74 | NPC1 (0.47) | NPC1 | |
| SCHEMBL7338919 | 0.74 | NPC1 (0.33) | NPC1 | |
| SCHEMBL7339433 | 0.74 | NPC1 (0.33) | NPC1 | |
| SCHEMBL7341962 | 0.73 | GAA (0.35) | NPC1 | |
| SCHEMBL7348591 | 0.73 | GAA (0.35) | NPC1 | |
| SCHEMBL7337076 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | claimed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | claimed |
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | disclosed |
| US-5444082-A | Treats hypertension and heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-08-22 | — | — | US | disclosed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | disclosed |