Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341962 | 1.00 | GAA (0.35) | GAAMAPTL3MBTL1KCNH2HRH3 | |
| SCHEMBL7339433 | 0.81 | NPC1 (0.33) | HRH3NPC1 | |
| SCHEMBL7338919 | 0.81 | NPC1 (0.33) | HRH3NPC1 | |
| SCHEMBL7339687 | 0.77 | GAA (0.39) | GAAMAPTL3MBTL1 | |
| SCHEMBL7339679 | 0.77 | GAA (0.39) | GAAMAPTL3MBTL1 | |
| SCHEMBL7338321 | 0.76 | GAA (0.36) | GAAMAPTL3MBTL1 | |
| SCHEMBL7338313 | 0.76 | GAA (0.36) | GAAMAPTL3MBTL1 | |
| SCHEMBL7341966 | 0.75 | KCNH2 (0.31) | KCNH2HRH3NPC1 | |
| SCHEMBL7339101 | 0.73 | NPC1 (0.37) | NPC1 | |
| SCHEMBL7339093 | 0.73 | NPC1 (0.37) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | claimed |
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | disclosed |
| US-5444082-A | Treats hypertension and heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-08-22 | — | — | US | disclosed |