Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.63 |
| ▸ | C1R | P00736 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333539 | 0.89 | ELANE (0.74) | ELANEC1RNPC1RAB9ALMNA | |
| SCHEMBL7363986 | 0.85 | ELANE (0.66) | ELANEC1R | |
| SCHEMBL7329441 | 0.83 | ELANE (0.63) | ELANEC1R | |
| SCHEMBL7335445 | 0.82 | C1R (0.62) | ELANEC1RALDH1A1MAPTHPGD | |
| SCHEMBL7332639 | 0.81 | ELANE (0.63) | ELANEC1RALDH1A1NPC1RAB9A | |
| SCHEMBL7338273 | 0.80 | ELANE (0.58) | ELANEC1RALDH1A1KDM4EHPGD | |
| SCHEMBL7367511 | 0.80 | ELANE (0.58) | ELANEC1RALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8897422 | 0.79 | ELANE (0.63) | ELANEC1R | |
| SCHEMBL7337764 | 0.79 | ELANE (0.63) | ELANEC1RNPC1RAB9AHTT | |
| SCHEMBL7332303 | 0.78 | ELANE (1.00) | ELANEC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |