SCHEMBL7339535

SCHEMBL7339535

Cc1cc(NC(=O)c2ccccc2-c2ccccc2)ccc1C(=O)N1Cc2ccccc2Cc2ccccc21

nearest known ligand 0.64

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 15/20 0.63
AVPR1A P37288 6/20 0.58
OXTR P30559 1/20 0.54
LMNA P02545 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8562010 0.89 AVPR2 (0.64) AVPR2AVPR1AOXTR
SCHEMBL7336291 0.89 AVPR2 (0.73) AVPR2AVPR1A
SCHEMBL7369344 0.87 AVPR2 (0.70) AVPR2AVPR1AOXTR
SCHEMBL7344791 0.86 AVPR2 (0.59) AVPR2AVPR1AOXTRLMNA
SCHEMBL7335141 0.81 AVPR2 (0.54) AVPR2AVPR1AOXTRLMNA
SCHEMBL7334113 0.81 AVPR2 (0.54) AVPR2AVPR1AOXTRLMNA
SCHEMBL8557043 0.80 AVPR2 (0.72) AVPR2AVPR1AOXTR
SCHEMBL7342906 0.79 AVPR2 (0.49) AVPR2AVPR1ALMNA
SCHEMBL8560800 0.79 AVPR2 (0.79) AVPR2AVPR1AOXTR
SCHEMBL7343092 0.78 AVPR2 (0.59) AVPR2AVPR1AOXTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996022282-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1996-07-25 WO claimed