Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.76 |
| ▸ | EDNRB | P24530 | 12/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970229 | 1.00 | EDNRA (0.76) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL6150870 | 0.86 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL27455228 | 0.86 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL7716850 | 0.79 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL7951249 | 0.77 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL5324171 | 0.77 | EDNRA (0.73) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL23467 | 0.77 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL7860467 | 0.77 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL7856711 | 0.77 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL788644 | 0.77 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |