SCHEMBL7339586

SCHEMBL7339586

CCCC1C(=O)N(Cc2ccccc2)S(=O)(=O)N1CC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.44
ELANE P08246 3/20 0.40
MEN1 O00255 3/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
KDM4E B2RXH2 1/20 0.39
PKM P14618 1/20 0.39
CA12 O43570 1/20 0.38
CA9 Q16790 1/20 0.38
TDP1 Q9NUW8 1/20 0.36
EHMT2 Q96KQ7 1/20 0.36
ALDH1A1 P00352 3/20 0.36
GAA P10253 1/20 0.36
TSHR P16473 1/20 0.36
HSD17B10 Q99714 1/20 0.36
PRKCA P17252 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7335115 0.86 ELANE (0.53) KMT2AELANEMEN1CYP1A2CYP2C9
SCHEMBL7328809 0.71 ELANE (0.53) KMT2AELANEMEN1PKMALDH1A1
SCHEMBL9083271 0.71 ELANE (0.80) ELANE
SCHEMBL7332181 0.70 KMT2A (0.45) KMT2AMEN1CYP1A2CYP2C9CYP2C19
SCHEMBL7465763 0.68 EP300 (0.44) KMT2AELANEMEN1CYP1A2CYP2C9
SCHEMBL7330348 0.66 ELANE (0.50) KMT2AELANEMEN1CYP1A2CYP2C9
SCHEMBL7329890 0.66 KDM4E (0.46) KMT2AELANEMEN1CYP1A2CYP2C9
SCHEMBL12169467 0.65 MEN1 (0.44) KMT2AELANEMEN1CYP2C19L3MBTL1
SCHEMBL21468553 0.65 KMT2A (0.45) KMT2AELANEMEN1SMN1; SMN2ALDH1A1
SCHEMBL6780344 0.63 MEN1 (0.58) KMT2AMEN1SMN1; SMN2NPSR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0793494-A4 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP INC (US) 1998-01-28 EP disclosed
EP-0793494-A1 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP, INC. (US) 1997-09-10 EP disclosed
US-5556909-A PROTEOLYTIC ENZYME INHIBITOR, TREATMENT OF DEGENERATIVE DISEASES, SUCH AS EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS SANOFI WINTHROP INC. (US) 1996-09-17 US disclosed
WO-1996016649-A1 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP, INC. (US) 1996-06-06 WO disclosed
US-5494925-A TREATING DEGENERATIVE DISORDERS; PROTEOLYTIC ENZYME INHIBITOR STERLING WINTHROP INC. (US) 1996-02-27 US disclosed